{"id":9088,"date":"2024-02-15T14:43:01","date_gmt":"2024-02-15T13:43:01","guid":{"rendered":"https:\/\/www.innov-ia.com\/?p=9088"},"modified":"2025-06-26T11:16:54","modified_gmt":"2025-06-26T09:16:54","slug":"focus-technologique-le-dripping","status":"publish","type":"post","link":"https:\/\/www.innov-ia.com\/fr\/focus-technologique-le-dripping\/","title":{"rendered":"FOCUS TECHNOLOGIQUE : LE DRIPPING"},"content":{"rendered":"

\"\"<\/p>\n

L\u2019encapsulation fait r\u00e9f\u00e9rence \u00e0 l\u2019ensemble des technologies permettant de formuler un (ou plusieurs) ingr\u00e9dient(s) actif(s) au sein de particules individualis\u00e9es pr\u00e9sentant une structure et des propri\u00e9t\u00e9s sp\u00e9cifiques. Parmi les principaux proc\u00e9d\u00e9s utilis\u00e9s industriellement figurent les techniques dites de dripping ou \u00ab\u00a0goutte-\u00e0-goutte\u00a0\u00bb.<\/p>\n

Le dripping repose sur la formation de gouttelette par extrusion d\u2019une solution de (bio)polym\u00e8re(s) contenant le(s) ingr\u00e9dient(s) actif(s) \u00e0 encapsuler \u00e0 travers une aiguille, une buse ou un injecteur. Les gouttelettes form\u00e9es vont tomber dans un bain de g\u00e9lification (Figure 1), ou bien solidifier dans un air froid ou \u00e0 temp\u00e9rature ambiante (lorsque le liquide extrud\u00e9 est un mat\u00e9riau fondu).<\/p>\n

\"\"<\/p>\n

Figure 1: Encapsulation d\u2019un ingr\u00e9dient actif dans des billes d\u2019hydrogel par dripping simple extrusion<\/h6>\n

Le principal int\u00e9r\u00eat du dripping r\u00e9side dans la production de (micro)particules quasi \u00ab monodisperses \u00bb (distribution de taille \u00e9troite, i.e., \u00e9cart-type inf\u00e9rieur \u00e0 10% de la taille moyenne), avec plusieurs structures finales possibles\u00a0: syst\u00e8mes matriciels vs syst\u00e8mes r\u00e9servoirs.<\/p>\n

\"\"<\/p>\n

Les gouttelettes g\u00e9n\u00e9r\u00e9es par simple gravit\u00e9 conduisent typiquement \u00e0 la formation de particules millim\u00e9triques. La diminution de taille en dessous du millim\u00e8tre suppose l\u2019utilisation d\u2019une force additionnelle \u00e0 la gravit\u00e9\u00a0: application d\u2019un potentiel \u00e9lectrostatique, rupture de jet (par application d\u2019une vibration \u00e0 une certaine fr\u00e9quence ou via le passage r\u00e9p\u00e9t\u00e9 d\u2019un \u00e9l\u00e9ment coupant), ou encore force centrifuge.<\/p>\n

Les mat\u00e9riaux d\u2019encapsulation utilis\u00e9s sont le plus souvent des biopolym\u00e8res g\u00e9lifiants, qui ont l\u2019avantage d\u2019\u00eatre biocompatibles et permettent une encapsulation dans des conditions douces, pr\u00e9servant ainsi l\u2019int\u00e9grit\u00e9 des ingr\u00e9dients actifs. L\u2019alginate, un polysaccharide obtenu \u00e0 partir d’algues brunes, constitue incontestablement le mat\u00e9riau de pr\u00e9dilection en mati\u00e8re de dripping. L\u2019alginate g\u00e9lifie en pr\u00e9sence de cations divalents (g\u00e9lification ionotropique) et permet l\u2019obtention de structures c\u0153ur-membrane par g\u00e9lification inverse (Figure 2B). Les billes d\u2019alginate peuvent \u00eatre utilis\u00e9es directement sous forme humide ou bien apr\u00e8s s\u00e9chage (s\u00e9cheur \u00e0 plateaux, s\u00e9cheur \u00e0 tambour rotatif, lit d\u2019air fluidis\u00e9), en fonction de l\u2019application finale vis\u00e9e.<\/p>\n

\"\"<\/p>\n

Figure 2: Encapsulation d\u2019huile dans des billes d\u2019alginate obtenues en dripping simple extrusion par A) g\u00e9lification ionotropique classique (structure matricielle)\u00a0; B) g\u00e9lification ionotropique inverse (structure c\u0153ur-membrane)<\/em><\/h6>\n

Les techniques de dripping font partie int\u00e9grante du portfolio de technologies propos\u00e9es par Capsulae pour accompagner ses clients dans la conception et le d\u00e9veloppement de produits innovants. Plusieurs \u00e9quipements aux \u00e9chelles laboratoire et pilote (jusqu\u2019\u00e0 100L de billes humides par jour) sont disponibles, incluant notamment des syst\u00e8mes simple buse et multi-buses, simple extrusion ou co-extrusion, permettant la g\u00e9n\u00e9ration de gouttelettes par simple gravit\u00e9 ou par rupture de jet (Figure 3).<\/p>\n

\"\"<\/p>\n

Figure 3: A) Encapsulateur B-390 \/ B-395 (B\u00fcchi)\u00a0; B) Equipement pilote semi-automatis\u00e9 (Capsulae)<\/em><\/h6>\n

La typologie d\u2019ingr\u00e9dients actifs pouvant \u00eatre encapsul\u00e9s par dripping est diverse et vari\u00e9e\u00a0: compos\u00e9s hydrophiles ou lipophiles, sous forme liquide ou solide, incluant ar\u00f4mes, parfums, vitamines, extraits de plantes, cellules, microorganismes, enzymes, etc\u2026 Le dripping trouve ainsi des applications dans un large \u00e9ventail de secteurs industriels\u00a0: alimentation humaine (cuisine mol\u00e9culaire, perles de saveur, \u00ab\u00a0bubble tea\u00a0\u00bb\u2026), cosm\u00e9tique (effet visuel \u00ab\u00a0caviar\u00a0\u00bb), biotechnologies (r\u00e9acteur \u00e0 enzymes ou cellules immobilis\u00e9es), domaines pharmaceutique et v\u00e9t\u00e9rinaire, protection des cultures et biocontr\u00f4le, traitement des sols et des eaux\u2026<\/p>\n

Sur l\u2019ensemble de ces march\u00e9s, Capsulae met \u00e0 disposition de ses clients une expertise reconnue et un savoir-faire de plus de trente ans en mati\u00e8re de technologies de dripping.<\/strong><\/p>\n

N\u2019h\u00e9sitez pas \u00e0 nous challenger et nous soumettre vos projets innovants\u00a0!<\/strong><\/p>\n

—-<\/p>\n

Capsulae Research and Innovation Center,<\/a>\u00a0 filiale d’ INNOV’IA<\/a><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

L\u2019encapsulation fait r\u00e9f\u00e9rence \u00e0 l\u2019ensemble des technologies permettant de formuler un (ou plusieurs) ingr\u00e9dient(s) actif(s) au sein de particules individualis\u00e9es pr\u00e9sentant une structure et des propri\u00e9t\u00e9s sp\u00e9cifiques. Parmi les principaux […]<\/p>\n","protected":false},"author":10,"featured_media":9058,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[89],"tags":[117,119,96],"class_list":["post-9088","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-capsulae-2","tag-dripping-fr","tag-encapsulation","tag-microencapsulation-fr"],"acf":[],"yoast_head":"\nFocus sur la technologie Dripping par Innov'ia<\/title>\n<meta name=\"description\" content=\"D\u00e9couvrez comment la technologie Dripping am\u00e9liore l'encapsulation avec pr\u00e9cision chez Innov'ia.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.innov-ia.com\/fr\/focus-technologique-le-dripping\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" 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